In a recent randomized, double-blind, placebo-controlled clinical trial that is awaiting peer review, the probiotic ingredient, L. rhamnosus HA-114, from Lallemand Health Solutions (Mirabel, Canada), improved eating and mood-related behaviors in overweight adults who were undergoing diet-induced weight loss.
In the study, 152 overweight but otherwise healthy subjects that began a personalized energy-restricted dietary intervention were given either 10 billion CFU of L. rhamnosus or placebo for 12 weeks. Researchers measured anthropometric parameters, body composition, biochemical analysis including cholesterol, triglycerides, insulin and insulin resistance levels. eating behavior, and psychological parameters, as well as eating behavior and psychological parameters using validated questionnaires. Results showed that nutritional intervention significantly changed body composition in both group, with no significant differences between then, supplementation with the probiotic did significantly alter eating behaviors and mood.
For example, subjects taking the probiotic saw increased self control, less binge eating, and fewer cravings. Additionally, subjects in the probiotic group also experienced less perceived stress, anxiety, and depression.
“We are extremely excited about these new insights. L. rhamnosus HA-114 is an innovative strain that has shown its capacity to support weight management efforts in overweight adults undertaking a weight loss program,” said Morgane Maillard, marketing group manager at Lallemand Health Solutions, in a press release. “It will allow us to formulate unique probiotic solutions for our partners available in convenient galenic formats, such as caps, sachets, orodispersible stick, etc. Consumers are health-aware and are looking for natural ways to take care of themselves, so the market opportunities are real. This study is paving the way to further investigation in the field of metabolic health, where there are abundant health applications.”
These results affirm the applicability of the brain-gut axis concept and demonstrate the influence of this probiotic strain on psychological wellbeing among participants engaging in a caloric-restriction intervention.